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Ko-143

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产品名称: Ko-143
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简单介绍

CAS:461054-93-3Formula:C26H35N3O5MW:469.578Appearance:Solid


Ko-143  的详细介绍

 BCRP inhibitor

Additional Information

Product #K-2013
CAS #461054-93-3
FormulaC26 H35 N3 O5
MW469.578
AppearanceSolid
SolubilitySoluble in DMSO (>25 mg/ml), ethanol (100 mM), and water
Melting Point147 °C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseKo 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell

Additional Information

MDL NumberMFCD11042273
ChemACXX1722231-4
InChIInChI=1S/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)/t18-,20-,21-/m0/s1
SMILESCC(C)C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H](NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC
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