Kainic acid is a natural marine product originally isolated from the red marine alga D. Simplex. It is a potent central nervous system stimulant, acting through specific kainate receptors and has been developed as the prototype neuroexcitatory amino acid for the induction of seizures in experimental animals, at a typical dose of 10-30 mg/kg in mice. Kainic acid is utilised in primary neuronal cell cultures and acute brain slice preparations to study the physiological effect of excitotoxicity and assess the neuroprotective capabilities of potential therapeutics.
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