JM6

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产品名称: JM6

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简单介绍

CAS:1008119-83-2Formula:C23H26N4O6S2MW:518.61Appearance:Off-WhiteSolidPurity:98%byHPLC

JM6 的详细介绍

Cell-permeable. A slow-release prodrug version of Ro 61-8048, an inhibitor of KMO (kynurenine 3-monoxygenase), the enzyme that controls the kynurenine pathway, long believed to be implicated in neurodegeneration. JM6 reverses and prevents symptoms of neurodegenerative diseases like Alzheimers and Huntingtons in animal models. JM6 does not penetrate into the brain, but works by inhibiting KMO in the blood.

Additional Information

Synonyms	2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-Nitrophenyl)-5-(Piperidin-1-yl)Methylthiazole
Product #	J-2368
CAS #	1008119-83-2
Chemical Name	2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-Nitrophenyl)-5-(Piperidin-1-yl)Methylthiazole
Formula	C₂₃H₂₆N₄O₆S₂
MW	518.61
Appearance	Off-White Solid
Purity	98% by HPLC
Solubility	DMSO
Storage Temp	-20°C
Therapeutic Area	Neurological Disorders
Use	JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO) prevents spatial memory deficits, anxiety-related behavior,Alzheimer disease

Additional Information

MDL Number	MFCD22380618
ChemACX	X5289403-0
InChI	InChI=1S/C23H26N4O6S2/c1-32-19-10-9-18(14-20(19)33-2)35(30,31)25-23-24-22(16-7-6-8-17(13-16)27(28)29)21(34-23)15-26-11-4-3-5-12-26/h6-10,13-14H,3-5,11-12,15H2,1-2H3,(H,24,25)
SMILES	COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=C(S2)CN3CCCCC3)C4=CC(=CC=C4)[N+](=O)[O-])OC

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