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AGScientific
JK 184
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产品名称:
JK 184
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简单介绍
CAS:315703-52-7Formula:C19H18N4OSMW:350.44Appearance:BeigeSolidPurity:98%byHPLC
JK 184
的详细介绍
An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC= 210 nM).
Additional Information
Synonyms
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-y l)-2-thiazolamine
Product #
J-2367
CAS #
315703-52-7
Chemical Name
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-y l)-2-thiazolamine
Formula
C
19
H
18
N
4
OS
MW
350.44
Appearance
Beige Solid
Purity
98% by HPLC
Solubility
Soluble in DMSO (100 mM) and Ethanol (25 mM)
Melting Point
235.63 °C
Storage Temp
-20°C
Therapeutic Area
Oncological Disorders
Use
Potent Hedgehog signaling inhibitor.JK 184 exhibits antiproliferative activity in a range of cancer cell
Additional Information
MDL Number
MFCD01044465
ChemACX
X1763998-0
InChI
InChI=1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)
SMILES
CCOc1ccc(cc1)Nc2nc(cs2)c3c(nc4n3cccc4)C
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