Herbimycin A, Streptomyces Hygroscopicus

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产品名称: Herbimycin A, Streptomyces Hygroscopicus

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简单介绍

CAS:70563-58-5Formula:C30H42N2O9MW:574.7Appearance:YellowPowderPurity:98%

Herbimycin A, Streptomyces Hygroscopicus 的详细介绍

A benzoquinoid ansamycin antibiotic that acts as a cell permeable inhibitor of tyrosine kinase and inducer of Heat Shock Proteins. Hsp90 inhibitor. Demonstrates anti-angiogenesis activity.

Additional Information

Synonyms	Antibiotic TAN 420F
Product #	H-1050
CAS #	70563-58-5
Chemical Name	[(2R,3S,5S,6R,7S,8E,10S,11S,12Z,14E)-2,5,6,11-TETRAMETHOXY-3,7,9,15-TETRAMETHYL-16,20,22-TRIOXO-17-AZABICYCLO[16.3.1]DOCOSA-1(21),8,12,14,18-PENTAEN-10-YL] CARBAMATE
Formula	C₃₀H₄₂N₂O₉
MW	574.7
Appearance	Yellow Powder
Purity	98%
Solubility	Soluble in Water, Methanol, and DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Effect of herbimycin A, an inhibitor of tyrosine kinase, on protein tyrosine kinase activity and phosphotyrosyl proteins of Ph1-positive leukemia cells

Additional Information

MDL Number	MFCD00151702
ChemACX	X1091564-1
InChI	InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
SMILES	C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C=C([C@@H]1OC)C2=O)/C)OC)OC(=O)N)C)C)OC)OC

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