GSK-1120212

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产品名称: GSK-1120212

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简单介绍

CAS:871700-17-3Formula:C26H23FIN5O4MW:615.39Appearance:Off-WhiteSolidPurity:98%byHPLC

GSK-1120212 的详细介绍

A potent and selective allosteric inhibitor of the MEK1 (IC= 0.7 nM) and MEK2 (IC= 0.9 nM) enzymes with potential antineoplastic activity.

Synonyms	N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide; JTP-74057
Product #	G-2339
CAS #	871700-17-3
Chemical Name	N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide; JTP-74057
Formula	C₂₆H₂₃FIN₅O₄
MW	615.39
Appearance	Off-White Solid
Purity	98% by HPLC
Solubility	DMSO (~ 10 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A potent and selective allosteric inhibitor of the MEK1 and MEK2 enzymes with potential antineoplastic activity

MDL Number	MFCD17215075
ChemACX	X3162736-6
InChI	InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
SMILES	CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5

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