Geninthiocin

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产品名称: Geninthiocin

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简单介绍

CAS:158792-27-9Formula:C50H49N15O15SMW:1132.1Appearance:WhiteAmorphousPowderPurity:>95%byHPLC

Geninthiocin 的详细介绍

*Please inquire the availability for this product. Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

Additional Information

Synonyms	14-Demethylberinamycin
Product #	G-2509
CAS #	158792-27-9
Formula	C50H49N15O15S
MW	1132.1
Appearance	White Amorphous Powder
Purity	>95% by HPLC
Solubility	Soluble in methanol, DMF, DMSO, and ethanol
Melting Point	270-275 °C
Storage Temp	4°C
Therapeutic Area	Infectious Diseases
Use	A thiopeptide antibiotic tipA gene activator

Additional Information

MDL Number	MFCD09752730
InChI	InChI=1S/C50H49N15O15S/c1-12-27-48-61-30(16-79-48)41(72)54-21(5)39(70)65-35(50(10,11)77)45(76)57-23(7)47-64-33(25(9)80-47)44(75)55-20(4)38(69)56-22(6)46-60-29(15-78-46)34-26(49-62-31(17-81-49)42(73)63-32(24(8)66)43(74)59-27)13-14-28(58-34)40(71)53-19(3)37(68)52-18(2)36(51)67/h12-17,24,32,35,66,77H,2-7H2,1,8-11H3,(H2,51,67)(H,52,68)(H,53,71)(H,54,72)(H,55,75)(H,56,69)(H,57,76)(H,59,74)(H,63,73)(H,65,70)/b27-12+
SMILES	C/C=C/1\c2nc(co2)C(=O)NC(=C)C(=O)NC(C(=O)NC(=C)c3nc(c(o3)C)C(=O)NC(=C)C(=O)NC(=C)c4nc(co4)-c5c(ccc(n5)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)-c6nc(cs6)C(=O)NC(C(=O)N1)C(C)O)C(C)(C)O

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