Gefitinib

点击看大图

如果您对该产品感兴趣的话,可以

产品名称: Gefitinib

产品型号:

产品展商: 其它品牌

产品文档: 无相关文档

简单介绍

CAS:184475-35-2Formula:C22H24ClFN4O3MW:446.9Appearance:AcrystallineSolidPurity:98%

Gefitinib 的详细介绍

Over-activity of the epidermal growth factor receptor-associated tyrosine kinase (EGFR-TK) has been associated with a number of cancers and thus TK inhibitors could be potential therapeutic agents to prevent malignant growth. Gefitinib is a selective inhibitor of EGFR-TK inhibitor that blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-Ras breast cancer, and OVCAR-3 ovarian cancer cell lines with ICs ranging between 0.2-0.4M. By interfering with the intracellular kinase domain, gefitinib prevents EGFR auto-phosphorylation and prevents downstream signal transduction. Gefitinib has been used to treat advanced (or recurrent) non-small cell lung cancer. However, the FDA retracted its general approval for this compound (Iressa) when a phase III trial failed to demonstrate an overall survival benefit. Gefitinib appears to be most efficacious in treating certain EGFR gene mutations that are prevalent in Asian populations.

Additional Information

Synonyms	Iressa, ZD1839
Product #	C-1251
CAS #	184475-35-2
Chemical Name	N-(3-chloro-4fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
Formula	C₂₂H₂₄ClFN₄O₃
MW	446.9
Appearance	A crystalline Solid
Purity	98%
Solubility	Soluble in ethanol (0.3 mg/ml), DMSO (20 mg/ml) or DMF (20 mg/ml), which should be purged of inert gas. Gefitinib is sparingly soluble in aqueous buffers.(For more information, please read Cof A).
Melting Point	193-194 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An EGFR-tyrosine kinase inhibitor use in cancer

Additional Information

MDL Number	MFCD04307832
ChemACX	X1511922-9
InChI	InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
SMILES	COc1cc2c(cc1OCCCN3CCOCC3)c(ncn2)Nc4ccc(c(c4)Cl)F

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!