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GANT58

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产品名称: GANT58
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简单介绍

CAS:64048-12-0Formula:C24H16N4SMW:392.48Appearance:YellowSolidPurity:98%byHPLC


GANT58  的详细介绍
Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC~ 5 M in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.

Additional Information

Synonyms2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503
Product #G-2333
CAS #64048-12-0
Chemical Name2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503
FormulaC24H16N4S
MW392.48
AppearanceYellow Solid
Purity98% by HPLC
SolubilityDMSO (25 mM) or Ethanol (25 mM)
Melting Point256-258 °C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseInhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells

Additional Information

MDL NumberMFCD01103196
ChemACXX1197193-8
InChIInChI=1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H
SMILESc1cnccc1c2c(c(sc2c3ccncc3)c4ccncc4)c5ccncc5
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