FTY720 | CAS# 162359-56-0 | Aids Transplant survival | A.G. Scientific | The ef

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产品名称: FTY720 | CAS# 162359-56-0 | Aids Transplant survival | A.G. Scientific | The ef

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简单介绍

CAS:162359-56-0Formula:C19H33NO2.HClMW:343.9Appearance:CrystallineSolidPurity:98%

FTY720 | CAS# 162359-56-0 | Aids Transplant survival | A.G. Scientific | The ef 的详细介绍

FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herbIscaria sinclari as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1p) receptors. Down-regulation of S1P receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch. FTY720 also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C transporter Abcc1 and inhibits cystolic phospholipase A activity.

Additional Information

Synonyms	Fingolimod
Product #	F-1162
CAS #	162359-56-0
Chemical Name	2-AMINO-2-(4-OCTYLPHENETHYL)PROPANE-1,3-DIOL HYDROCHLORIDE
Formula	C₁₉H₃₃NO₂.HCl
MW	343.9
Appearance	Crystalline Solid
Purity	98%
Solubility	Soluble in DMSO (10 mg / ml), 100% ethanol or Dimethyl formamide.
Melting Point	102-107 °C
Storage Temp	-20°C
Therapeutic Area	Neurological Disorders
Use	FTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator for treating multiple sclerosis

Additional Information

MDL Number	MFCD00939512
ChemACX	X1494471-1
InChI	InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
SMILES	CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N.Cl

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