Fosfomycin Disodium Salt is an antibiotic produced by Streptomyces fradiae. It is a phosphoenolpyruvate analog that irreversibly inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme involved in bacterial cell wall biosynthesis. This, in turn, inhibits the production of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall. Fosfomycin disodium salt concentrates in the kidney and bladder, thereby reducing nephrotoxicity and ototoxicity of platinum-containing antitumor agents
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