Florfenicol

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产品名称: Florfenicol

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简单介绍

CAS:73231-34-2Formula:C12H14Cl2FNO4SMW:358.2Appearance:WhitesolidPurity:>99%byHPLC

Florfenicol 的详细介绍

*Please inquire the availability for this product. Florfenicol is synthesised from thiamphenicol by replacing the 3-hydroxy group with fluorine, first synthesised at Schering in 1980. By replacing the hydroxy group, it was rationalised that chloramphenicol resistance via chloramphenicol acetyltransferase could be eliminated. Florfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Florfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Florfenicol has been extensively studied with over 400 literature citations.

Additional Information

Synonyms	(-)Florfenicol, Sch 25298
Product #	F-2433
CAS #	73231-34-2
Formula	C12H14Cl2FNO4S
MW	358.2
Appearance	White solid
Purity	>99% by HPLC
Solubility	Soluble in ethanol (50 mg/ml), DMSO (100 mM), water (132 mg/ml, pH 7), acetone, and DMF
Melting Point	153-157 °C
Storage Temp	4°C
Therapeutic Area	Infectious Diseases
Use	Florfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria

Additional Information

MDL Number	MFCD00864834
InChI	InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1
SMILES	CS(=O)(=O)c1ccc(cc1)[C@H]([C@@H](CF)NC(=O)C(Cl)Cl)O

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