Fidaxomicin

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产品名称: Fidaxomicin

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简单介绍

CAS:873857-62-6Formula:C52H74Cl2O18MW:1058Appearance:WhitesolidPurity:>98%byHPLC

Fidaxomicin 的详细介绍

*Please inquire the availability for this product. Fidaxomicin is a recently marketed antibiotic with a confusing history dating back to its original isolation in 1975. Fidaxomicin is the major analogue of a family of macrocyclic lactones, isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microMSTl flora.

Additional Information

Synonyms	Clostomicin B1, Lipiarmycin A3, Tiacumicin B, OPT 80
Product #	F-2425
CAS #	873857-62-6
Formula	C52H74Cl2O18
MW	1058
Appearance	White solid
Purity	>98% by HPLC
Solubility	Soluble in ethanol, methanol, DMF, DMSO, and Limited water solubility
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	Fidaxomicin is a narrow spectrum antibiotic, inhibiting bacterial RNA polymerase and demonstrates excellent activity against Gram positive bacteria

Additional Information

MDL Number	MFCD27976367
InChI	InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19+,26-22+,27-21+,31-17+/t28-,29-,30+,33+,34+,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1
SMILES	CC[C@H]1/C=C(/[C@H](C/C=C/C=C(/C(=O)O[C@@H](C/C=C(/C=C(/[C@@H]1O[C@H]2[C@H]([C@H]([C@@H](C(O2)(C)C)OC(=O)C(C)C)O)O)\C)\C)[C@@H](C)O)\CO[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)\C

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