EZSolution CHIR99021

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产品名称: EZSolution CHIR99021

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简单介绍

CAS:252917-06-9Formula:C22H18Cl2N8MW:465.34Appearance:LiquidPurity:98%byHPLC

EZSolution CHIR99021 的详细介绍

CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β. It activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle and it has also been shown to induce the reprogramming of murine and human somatic cells into stem cells

Additional Information

Synonyms	6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile; CT99021
Product #	E-2311
CAS #	252917-06-9
Chemical Name	6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile; CT99021
Formula	C₂₂H₁₈Cl₂N₈
MW	465.34
Appearance	Liquid
Purity	98% by HPLC
Melting Point	316.33 °C
Storage Temp	-20°C
Therapeutic Area	Endocrinological Disorders
Use	CHIR99021 is GSK3β kinase inhibitor enhances glucose metabolism in type 2 diabetes

Additional Information

MDL Number	MFCD11846251
ChemACX	X1755647-3
InChI	InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
SMILES	CC1=CNC(=N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N

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