Erlotinib Hydrochloride Salt

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产品名称: Erlotinib Hydrochloride Salt

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简单介绍

CAS:183319-69-9Formula:C22H23N3O4.HClMW:429.9Appearance:Whitetooff-whiteSolidPurity:99%byHPLC

Erlotinib Hydrochloride Salt 的详细介绍

Erlotinib is an inhibitor of human Epidermal growth factor receptor (EGFR) tyrosine kinase (IC= 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC= 20 nM). Studies in cell lines and enzyme assays have both shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl.

Additional Information

Synonyms	CP-358774, OSI-774
Product #	E-2307
CAS #	183319-69-9
Chemical Name	N-(3-ETHYNYLPHENYL)-6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4-AMINE HYDROCHLORIDE
Formula	C₂₂H₂₃N₃O₄.HCl
MW	429.9
Appearance	White to off-white Solid
Purity	99% by HPLC
Solubility	DMSO
Melting Point	223-225 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An HER-1/EGFR tyrosine kinase inhibitor used to treat non-small cell lung cancer (NSCLC), pancreatic cancer

Additional Information

MDL Number	MFCD07781272
ChemACX	X1511913-0
InChI	InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
SMILES	COCCOc1cc2c(cc1OCCOC)ncnc2Nc3cccc(c3)C#C.Cl

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