Epothilone B

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产品名称: Epothilone B

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简单介绍

CAS:152044-54-7Formula:C27H4NO6SMW:507.7Appearance:WhitetooffwhitepowderPurity:>98%byHPLC

Epothilone B 的详细介绍

*Please inquire the availability for this product. Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol , and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.

Additional Information

Synonyms	EpoB
Product #	E-2449
CAS #	152044-54-7
Formula	C₂₇H₄NO₆S
MW	507.7
Appearance	White to off white powder
Purity	>98% by HPLC
Solubility	Soluble in Chloroform, Dichloromethane, DMSO, Ethanol and Methanol
Melting Point	95-97°C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Epo B causes cell cycle arrest in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.

Additional Information

MDL Number	MFCD02101921
InChI	InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
SMILES	Cc1nc(cs1)/C=C(\C)/[C@@H]2C[C@H]3[C@](O3)(CCC[C@@H]([C@@H]([C@H](C(=O)C([C@H](CC(=O)O2)O)(C)C)C)O)C)C

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