Entinostat

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产品名称: Entinostat

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简单介绍

CAS:209783-80-2Formula:C21H20N4O3MW:376.41Appearance:CrystallineSolidPurity:99%byHPLC

Entinostat 的详细介绍

Preferentially inhibits HDAC1 (IC= 300 nM) over HDAC3 (IC= 8 M). Has no inhibitory activity towards HDAC8 (IC100 M).

Synonyms	MS-275, SNDX-275
Product #	M-2358
CAS #	209783-80-2
Chemical Name	[4-(2-AMINO-PHENYLCARBAMOYL)-BENZYL]-CARBAMIC ACID PYRIDIN-3-YLMETHYL ESTER
Formula	C₂₁H₂₀N₄O₃
MW	376.41
Appearance	Crystalline Solid
Purity	99% by HPLC
Solubility	DMSO (38 mg/ml)
Melting Point	158-160 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	HDAC inhibitor use in cancer

MDL Number	MFCD08272435
ChemACX	X1441359-3
InChI	InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
SMILES	c1ccc(c(c1)N)NC(=O)c2ccc(cc2)CNC(=O)OCc3cccnc3

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