Emetine dihydrochloride

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产品名称: Emetine dihydrochloride

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简单介绍

CAS:316-42-7Formula:C29H40N2O4MW:553.56Appearance:Whitetooff-whiteSolidPurity:98%bytitration

Emetine dihydrochloride 的详细介绍

A bitter-tasting crystalline alkaloid,derived from ipecac root and used in the treatment of amebiasis and as an emetic.Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures.

Additional Information

Synonyms	2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline
Product #	E-2304
CAS #	316-42-7
Chemical Name	2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline
Formula	C₂₉H₄₀N₂O₄
MW	553.56
Appearance	White to off-white Solid
Purity	98% by titration
Solubility	Soluble in Water (~ 100 mg/ml)
Storage Temp	+4°C
Therapeutic Area	Infectious Diseases
Use	Used in the treatment of amebiasis and as an emetic

Additional Information

MDL Number	MFCD00135589
ChemACX	X1005305-1
InChI	InChI=1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1
SMILES	CC[C@H]1CN2CCc3cc(c(cc3[C@@H]2C[C@@H]1C[C@@H]4c5cc(c(cc5CCN4)OC)OC)OC)OC.Cl.Cl

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