DZNep (102052-95-9) is a potent histone methyltransferase inhibitor which decreases global histone methylation. Inhibits trimethylation of H3K27 and H4K20 in vitro. Selectively induces apoptosis in multiple cancer cell lines with no effect on normal cells. DZNep may be used in cocktails to chemically induce pluripotent stem cells (CiPSCs) from somatic cells. Enhances angiogenesis in a mouse model of limb ischemia.
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