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DPP IV Inhibitor, NVP DPP 728

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产品名称: DPP IV Inhibitor, NVP DPP 728
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简单介绍

CAS:247016-69-9Formula:C15H18N6O.2HClMW:371.27Appearance:WhiteSolidPurity:98%byHPLC


DPP IV Inhibitor, NVP DPP 728  的详细介绍
A potent, selective, reversible, and slow binding dipeptidyl peptidase IV inhibitor (IC= 14 nM). Displays 15,000 fold selectivity over DPP-II and a range of Proline-cleaving proteases. Displays anti-diabetic activity in vivo, improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, and augments insulin secretion and GLUT-2 levels.

Additional Information

Synonyms6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile Dihydrochloride
Product #D-2295
CAS #247016-69-9
Chemical Name6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile Dihydrochloride
FormulaC15H18N6O.2HCl
MW371.27
AppearanceWhite Solid
Purity98% by HPLC
SolubilityDMSO (~100 mM) or EtOH (~ 100 mM)
Storage Temp-20°C
Therapeutic AreaEndocrinological Disorders
UseInhibition of dipeptidyl peptidase IV (DPP-IV) has been used to the treatment of type 2 diabetes

Additional Information

MDL NumberMFCD12828773
ChemACXX1764022-5
InChIInChI=1S/C15H18N6O.2ClH/c16-8-12-3-4-14(20-10-12)19-6-5-18-11-15(22)21-7-1-2-13(21)9-17;;/h3-4,10,13,18H,1-2,5-7,11H2,(H,19,20);2*1H/t13-;;/m0../s1
SMILESC1C[C@H](N(C1)C(=O)CNCCNC2=NC=C(C=C2)C#N)C#N.Cl.Cl
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