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Dimethylenastron

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产品名称: Dimethylenastron
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简单介绍

CAS:863774-58-7Formula:C16H18N2O2SMW:302.4Appearance:YellowSolidPurity:95%


Dimethylenastron  的详细介绍
Potent, cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC=200 nM) by binding to the mitotic kinesin Eg5.

Additional Information

Synonyms7,7-Dimethyl-4-(3-hydroxyphenyl)-5-oxo-3,4,5,6,7,8-hexahydroquinazolin-2(1H)-thione
Product #D-1300
CAS #863774-58-7
Chemical Name7,7-Dimethyl-4-(3-hydroxyphenyl)-5-oxo-3,4,5,6,7,8-hexahydroquinazolin-2(1H)-thione
FormulaC16H18N2O2S
MW302.4
AppearanceYellow Solid
Purity95%
SolubilitySoluble in DMSO (10mg/ml) or methanol (5mg/ml).
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseDimethylenastron suppresses human pancreatic cancer cell migration and invasion in inhibition of mitotic kinesin Eg5

Additional Information

MDL NumberMFCD09264157
ChemACXX4983319-2
InChIInChI=1S/C16H18N2O2S/c1-16(2)7-11-13(12(20)8-16)14(18-15(21)17-11)9-4-3-5-10(19)6-9/h3-6,14,19H,7-8H2,1-2H3,(H2,17,18,21)
SMILESCC1(CC2=C(C(NC(=S)N2)C3=CC(=CC=C3)O)C(=O)C1)C
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