Dasatinib | CAS 302962-49-8 | Multi-kinase Inhibitor | AG Scientific

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产品名称: Dasatinib | CAS 302962-49-8 | Multi-kinase Inhibitor | AG Scientific

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简单介绍

CAS:302962-49-8Formula:C22H26ClN7O2SMW:488.01Appearance:Whitetooff-whiteSolidPurity:99%byHPLC

Dasatinib | CAS 302962-49-8 | Multi-kinase Inhibitor | AG Scientific 的详细介绍

Dasatinib is a multi-kinase inhibitor with potent activity against BCRABL kinase (IC50 = 0.21.1 nM). Dasatinib also inhibits Lyn (IC= 8.5 nM) and Src (IC= 3.0 nM) kinase activities in vitro using 0.1 mg/mL poly (Glu4-Tyr) as the substrate. Dasatinib is used to treat certain ***** patients with Philadelphia chromosome-positive chronic myeloid leukemia (CML) or acute lymphoblastic leukemia (ALL).

Additional Information

Synonyms	BMS-354825, Sprycel
Product #	C-2281
CAS #	302962-49-8
Chemical Name	N-(2-CHLORO-6-METHYLPHENYL)-2-[[6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL]AMINO]-1,3-THIAZOLE-5-CARBOXAMIDE
Formula	C₂₂H₂₆ClN₇O₂S
MW	488.01
Appearance	White to off-white Solid
Purity	99% by HPLC
Solubility	DMSO (200 mg/ml)
Melting Point	261-285 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Src and Bcr/Abl kinase inhibitor

Additional Information

MDL Number	MFCD11046566
ChemACX	X1578549-6
InChI	InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
SMILES	Cc1cccc(c1NC(=O)c2cnc(s2)Nc3cc(nc(n3)C)N4CCN(CC4)CCO)Cl

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