D-1210, DAPT, 208255-80-5 DAPT Does not inhibit presenilinase. Antagonizes Notc

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产品名称: D-1210, DAPT, 208255-80-5 DAPT Does not inhibit presenilinase. Antagonizes Notc

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简单介绍

CAS:208255-80-5Formula:C23H26F2N2O4MW:432.5Appearance:WhitetoOff-whiteSolidPurity:98%

D-1210, DAPT, 208255-80-5 DAPT Does not inhibit presenilinase. Antagonizes Notc 的详细介绍

Cell permeable inhibitor of γ-secretase (IC=115 nM for totalamyloid, IC=200 nM foramyloid 1-42). Does not inhibit presenilinase. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stel cell-derived embryoid bodies independent of sonic hedgehog (Shh) signaling.

Additional Information

Synonyms	N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester
Product #	D-1210
CAS #	208255-80-5
Chemical Name	N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester
Formula	C₂₃H₂₆F₂N₂O₄
MW	432.5
Appearance	White to Off-white Solid
Purity	98%
Solubility	Soluble in100% Ethanol, DMSO, or Dichloromethane
Preparation	Aliquots should be stored at -20C, Stock solutions stable up to 3 months.
Storage Temp	-20°C
Therapeutic Area	Neurological Disorders
Use	A potent and specific inhibitor of γ-secretase use in Alzheimer’s disease

Additional Information

MDL Number	MFCD04974585
ChemACX	X1460779-7
InChI	InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
SMILES	C[C@@H](C(=O)N[C@@H](c1ccccc1)C(=O)OC(C)(C)C)NC(=O)Cc2cc(cc(c2)F)F

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