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Cyclopamine-KAAD

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产品名称: Cyclopamine-KAAD
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简单介绍

CAS:306387-90-6Formula:C44H63N3O4MW:697.99Appearance:PaleyellowSolidPurity:80%byHPLC


Cyclopamine-KAAD  的详细介绍
Cell-permeable. A synthetic derivative of the natural product Cyclopamine (Cat. No. 1578-5) that acts as a specific inhibitor of Smoothened (Smo) and Sonic hedgehog (Shh) intracellular signaling (IC=20 nM in the Shh-LIGHT2 assay).

Additional Information

Synonyms3-Keto-N-(aminoethyl-N-aminocaproyldihydrocinnamoyl)cyclopamine; KAAD-cyclopamine
Product #C-2277
CAS #306387-90-6
Chemical Name3-KETO-N-AMINOETHYL-N'-AMINOCAPROYLDIHYDROCINNAMOYL CYCLOPAMINE
FormulaC44H63N3O4
MW697.99
AppearancePale yellow Solid
Purity80% by HPLC
SolubilitySoluble in DMSO or EtOH
Storage Temp-20°C
UseCyclopamine-KAAD is a potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity

Additional Information

MDL NumberMFCD03425585
InChIInChI=1S/C44H63N3O4/c1-29-25-39-42(47(28-29)24-23-46-40(49)13-9-6-10-22-45-41(50)17-14-32-11-7-5-8-12-32)31(3)44(51-39)21-19-35-36-16-15-33-26-34(48)18-20-43(33,4)38(36)27-37(35)30(44)2/h5,7-8,11-12,15,29,31,35-36,38-39,42H,6,9-10,13-14,16-28H2,1-4H3,(H,45,50)(H,46,49)
SMILESCC1CC2C(C(C3(O2)CCC4C5CC=C6CC(=O)CCC6(C5CC4=C3C)C)C)N(C1)CCNC(=O)CCCCCNC(=O)CCc7ccccc7
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