CRT Inhibitor, iCRT5

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产品名称: CRT Inhibitor, iCRT5

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简单介绍

CAS:18623-44-4Formula:C16H17NO5S2MW:367.44Appearance:YellowSolidPurity:98%byHPLC

CRT Inhibitor, iCRT5 的详细介绍

Cell-permeable. A potent inhibitor of thecatenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an ICof 18 nM. It acts by disrupting the interaction betweencatenin and TCF4, possibly by direct binding tocatenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.

Additional Information

Synonyms	(Z)-4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid
Product #	C-2273
CAS #	18623-44-4
Chemical Name	(Z)-4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid
Formula	C₁₆H₁₇NO₅S₂
MW	367.44
Appearance	Yellow Solid
Purity	98% by HPLC
Solubility	DMSO
Storage Temp	-20°C
Use	Cell-permeable β-catenin-responsive transcription (CRT) inhibitor

Additional Information

MDL Number	MFCD00703657
ChemACX	X1474972-7
InChI	InChI=1S/C16H17NO5S2/c1-21-11-6-5-10(8-12(11)22-2)9-13-15(20)17(16(23)24-13)7-3-4-14(18)19/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,19)/b13-9-
SMILES	COc1ccc(cc1OC)/C=C2/C(=O)N(C(=S)S2)CCCC(=O)O

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