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Crizotinib

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产品名称: Crizotinib
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简单介绍

CAS:877399-52-5Formula:C21H22Cl2FN5OMW:450.34Appearance:Off-WhiteSolidPurity:98%byHPLC


Crizotinib  的详细介绍
A specific, ATP-competitive, small-molecule inhibitor of the receptor tyrosine kinases (RTKs) c-Met and anaplastic lymphoma kinase (ALK). Iinhibits tyrosine phosphorylation of activated ALK at nanomolar concentrations. Inhibits the growth and survival of cell lines dependent upon c-Met or ALK enzymatic activity.

Additional Information

Synonyms3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
Product #C-2272
CAS #877399-52-5
Chemical Name3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
FormulaC21H22Cl2FN5O
MW450.34
AppearanceOff-White Solid
Purity98% by HPLC
SolubilityDMSO
Melting Point202-204 °C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseCrizotinib is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor for treatment of some non-small cell lung carcinoma

Additional Information

MDL NumberMFCD12407409
ChemACXX1759586-1
InChIInChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
SMILESC[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
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