clasto-Lactacystin-b-lactone, Synthetic

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产品名称: clasto-Lactacystin-b-lactone, Synthetic

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简单介绍

CAS:155975-72-7Formula:C10H15NO4MW:213.2Appearance:WhiteSolidPurity:>95%

clasto-Lactacystin-b-lactone, Synthetic 的详细介绍

Synthetic. Highly specific, cell permeable, and irreversible 20S proteasome inhibitor. It is believed lactacystin acts as a precursor for clasto-lactacystin b-lactone. Parkin Directly Modulates 26S Proteasome Activity.ASK1 Negatively Regulates the 26 S Proteasome.Parkin Ubiquitinates and Promotes the Degradation of RanBP2.Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3.

Additional Information

Synonyms	Omualide
Product #	L-1055
CAS #	155975-72-7
Chemical Name	1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE
Formula	C₁₀H₁₅NO₄
MW	213.2
Appearance	White Solid
Purity	>95%
Solubility	Soluble in Chloroform or DMSO. Moderately Soluble in Water.
Melting Point	161.31 °C
Storage Temp	Store at -20°C. Stock solutions are stable for up to 1 month at -80°C.
Use	Effect of proteasome inhibitor clasto-lactacystin-beta-lactone on the proteome of the haloarchaeon Haloferax volcanii

Additional Information

MDL Number	MFCD01076526
ChemACX	X1094109-2
InChI	InChI=1S/C10H15NO4/c1-4(2)7-10(9(14)15-7)6(12)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10+/m1/s1
SMILES	O=C1O[C@@H](C(C)C)[C@]12NC(=O)[C@@H]([C@@H]2O)C

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