Chrysomycin B

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产品名称: Chrysomycin B

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简单介绍

CAS:83852-56-6Formula:C27H28O9MW:496.509Appearance:WhitePowder

Chrysomycin B 的详细介绍

Chrysomycin B is a minor analogue in a complex of C-glycoside anti-tumor actives isolated fromStreptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent anti-tumor active and an inhibitor of the catalytic activity of human topoisomerase II. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated crosslinkers of DNA to histones. Topoisomerase II Inhibitors. Inhibitors of the catalytic activity of human topoisomerase II. Exhibits anti-tumor activity against human cell lines K562, HT29, MCF7, PC6, MKN28.

Additional Information

Product #	C-1700
CAS #	83852-56-6
Formula	C₂₇ H₂₈ O₉
MW	496.509
Appearance	White Powder
Solubility	Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.
Storage Temp	+4°C
Therapeutic Area	Oncological Disorders
Use	Chrysomycin B is a minor analogue in a complex of C-glycoside anti-tumor actives isolated fromStreptomyces

Additional Information

MDL Number	MFCD07370132
ChemACX	X1495719-0
InChI	InChI=1S/C27H28O9/c1-11-8-15-19(17(9-11)33-4)14-10-18(34-5)21-16(28)7-6-13(20(21)22(14)36-26(15)31)23-25(30)27(3,32)24(29)12(2)35-23/h6-10,12,23-25,28-30,32H,1-5H3
SMILES	Cc1cc2c(c3cc(c4c(ccc(c4c3oc2=O)C5C(C(C(C(O5)C)O)(C)O)O)O)OC)c(c1)OC

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