Chrysomycin A

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产品名称: Chrysomycin A

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简单介绍

CAS:82196-88-1Formula:C28H28O9MW:508.5Appearance:YellowLyophilisatePurity:99%byHPLC

Chrysomycin A 的详细介绍

Chrysomycin A is the major analogue in a complex of C-glycoside antitumor actives, isolated from Streptomyces. Chrysomycin A, with a vinyl group in the 8-position, is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. Chrysomyin A has a potent antibacterial, antifungal, antiviral and antitumor profile. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated crosslinkers of DNA to histones.

Additional Information

Synonyms	Chrysomycin V, Albacarcin V, Virenomycin V,
Product #	C-1410
CAS #	82196-88-1
Chemical Name	8-ETHENYL-1-HYDROXY-10,12-DIMETHOXY-4-[(2S,3S,4R,5S,6R)-3,4,5-TRIHYDROXY-4,6-DIMETHYLOXAN-2-YL]NAPHTHO[1,2-C]ISOCHROMEN-6-ONE
Formula	C₂₈H₂₈O₉
MW	508.5
Appearance	Yellow Lyophilisate
Purity	99% by HPLC
Solubility	Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.
Storage Temp	+4°C
Therapeutic Area	Oncological Disorders
Use	Chrysomycin A is the major analogue in a complex of C-glycoside antitumor actives

Additional Information

MDL Number	MFCD07370133
ChemACX	X1495721-0
InChI	InChI=1S/C28H28O9/c1-6-13-9-16-20(18(10-13)34-4)15-11-19(35-5)22-17(29)8-7-14(21(22)23(15)37-27(16)32)24-26(31)28(3,33)25(30)12(2)36-24/h6-12,24-26,29-31,33H,1H2,2-5H3/t12-,24+,25+,26+,28-/m1/s1
SMILES	C[C@@H]1[C@@H]([C@@]([C@H]([C@@H](O1)c2ccc(c3c2c4c(cc3OC)c5c(cc(cc5OC)C=C)c(=O)o4)O)O)(C)O)O

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