Celastrol

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产品名称: Celastrol

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简单介绍

CAS:34157-83-0Formula:C29H38O4MW:450.61Appearance:RedSolidPurity:98%byTLC

Celastrol 的详细介绍

Cell-permeable.Proteasome inhibitor. An Antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC= 40 nM for IL-1 and IL-1, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF).Suppresses nitric oxide (NO) production (IC= 230 nM) and LPS-induced NF-B activation (IC= 270 nM).Inhibits chymotrypsin-like activity of 20S proteasome (IC= 2.5 M) and lipid peroxidation induced by ADP and Fe in rat liver mitochondria (IC= 7 M).

Additional Information

Synonyms	3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Product #	C-2262
CAS #	34157-83-0
Chemical Name	(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Formula	C₂₉H₃₈O₄
MW	450.61
Appearance	Red Solid
Purity	98% by TLC
Solubility	DMSO (45 mg/ml) or Ethanol (30 mg/ml)
Melting Point	219-230 °C
Storage Temp	-20°C
Therapeutic Area	Neurological Disorders
Use	Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease

Additional Information

MDL Number	MFCD03424073
ChemACX	X1463240-3
InChI	InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
SMILES	CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O

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