CDK1/2 Inhibitor III

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产品名称: CDK1/2 Inhibitor III

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简单介绍

Formula:C15H13F2N7O2S2MW:425.4Appearance:Whitetooff-whiteSolidPurity:95%byHPLC

CDK1/2 Inhibitor III 的详细介绍

Cell permeable triazolo-diamine compound;displays anti-proliferative properties inhuman cancer cells (IC50=20nM, 35nM and 92nM in HCT-116, HeLa, and A375 cells). Acts as a highly potent, ATP-competitive inhibitor of CDK1/cyclin B and CDK2/cyclin A (IC=600pM and 500pM) with selectivity over VEGF-R2 and GSK-3 (IC=32nM and 140nM).

Additional Information

Synonyms	5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
Product #	C-1447
Chemical Name	5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
Formula	C₁₅H₁₃F₂N₇O₂S₂
MW	425.4
Appearance	White to off-white Solid
Purity	95% by HPLC
Solubility	Soluble in DMSO (10mg/ml).
Storage Temp	-20°C

Additional Information

MDL Number	MFCD09264159
InChI	InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)
SMILES	c1cc(c(c(c1)F)NC(=S)n2c(nc(n2)Nc3ccc(cc3)S(=O)(=O)N)N)F

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