Calpain-1, Porcine Erythrocytes

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产品名称: Calpain-1, Porcine Erythrocytes

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MW:112000Appearance:Liquid

Calpain-1, Porcine Erythrocytes 的详细介绍

Native calpain-1 from porcine erythrocytes. The two major isoforms, calpain I (-form) and calpain II (m-form), differ in their calcium requirement for activation. Calpain I requires only micromolar amounts of calcium (EC = 2 M), while calpain II requires millimolar amounts (EC = 1 mM). Calpains are heterodimers of 80 kDa and 30 kDa subunits. The 80 kDa unit has the catalytic site and is unique to each isozyme. The 30 kDa unit is a regulatory subunit and common to both calpain I and calpain II. The 80 kDa unit consists of four domains (I-IV). The 30 kDa unit has two domains (V and VI). Domain I is partially removed during autolysis. Domain II is the protease domain. Domain III exhibits a homology with typical calmodulin binding proteins and interacts with calcium binding domains (IV and VI) and frees domain II for protease activity. Domain IV is a calcium binding domain. Domain V contains a hydrophobic region and is essential for calpain interaction with membranes. Domain VI is a calcium binding domain Specific Activity: 1200 units/mg protein. Unit Definition: One unit is defined as the amount of enzyme that will hydrolyze 1 pmol Suc-LLVY-AMC in 1 min at 25°C using the Calpain Activity Assay Kit, Fluorogenic. 1 caseinolytic unit = 9 fluorogenic units

Additional Information

Synonyms	μ-Calpain
Product #	C-1569
MW	112000
Appearance	Liquid
Storage Temp	-80°C

Additional Information

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