Calpain Inhibitor III

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产品名称: Calpain Inhibitor III

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简单介绍

CAS:88191-84-8Formula:C22H26N2O4MW:382.5Appearance:WhitelyophilizedSolidPurity:≥95%byHPLC

Calpain Inhibitor III 的详细介绍

A potent, cell-permeable inhibitor of calpain I and II (K = 8 nM).That also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.

Additional Information

Synonyms	MDL 28170, Z-Val-Phe-CHO
Product #	C-1549
CAS #	88191-84-8
Chemical Name	BENZYL-N-[(2S)-1-OXO-3-PHENYLPROPAN-2-YL]CARBAMATE
Formula	C₂₂H₂₆N₂O₄
MW	382.5
Appearance	White lyophilized Solid
Purity	≥95% by HPLC
Solubility	10 mg/ml in DMSO or ethanol, insoluble in water
Storage Temp	-20°C
Therapeutic Area	Neurological Disorders
Use	A cell permeable selective inhibitor of Calpain 1, has neuroprotective effects in spinal cord injury.

Additional Information

MDL Number	MFCD00798796
ChemACX	X1271586-5
InChI	InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1
SMILES	CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2

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