C75, FAS Inhibitor

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产品名称: C75, FAS Inhibitor

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简单介绍

CAS:191282-48-1Formula:C14H22O4MW:254.3Appearance:Off-WhiteSolidPurity:98%

C75, FAS Inhibitor 的详细介绍

Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of FAS. Down regulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activiate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant in vivo antitumor activity in human breast cancer cells.Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.

Additional Information

Product #	C-1373
CAS #	191282-48-1
Chemical Name	(2R,3S)-TETRAHYDRO-4-METHYLENE-2-OCTYL-5-OXO-3-FURANCARBOXYLIC ACID
Formula	C₁₄H₂₂O₄
MW	254.3
Appearance	Off-White Solid
Purity	98%
Solubility	Soluble in dichloromethane, methanol or DMSO.
Melting Point	142.14 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An inhibitor of FAS.Suppresses DNA replication and induces apoptosis shows significant antitumor activity in human breast cancer cells

Additional Information

MDL Number	MFCD03265452
ChemACX	X1355404-0
InChI	InChI=1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12+/m1/s1
SMILES	CCCCCCCC[C@@H]1[C@H](C(=C)C(=O)O1)C(=O)O

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