Butyrolactone I

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产品名称: Butyrolactone I

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简单介绍

CAS:87414-49-1Formula:C24H24O7MW:424.44Appearance:WhiteSolidPurity:99%byHPLC

Butyrolactone I 的详细介绍

Cell permeable. A potent and selective inhibitor of the cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5. Inhibits cell cycle progression at the G1/S and G2/M transitions. BLI is an important tool for probing the cellular roles of CDKs. It blocks Fas-induced apoptosis and displays antitumor activity.

Additional Information

Synonyms	BLI, BL-I
Product #	B-2211
CAS #	87414-49-1
Chemical Name	METHYL-4-HYDROXY-2-[[4-HYDROXY-3-(3-METHYLBUT-2-ENYL)PHENYL]METHYL]-3-(4-HYDROXYPHENYL)-5-OXOFURAN-2-CARBOXYLATE
Formula	C₂₄H₂₄O₇
MW	424.44
Appearance	White Solid
Purity	99% by HPLC
Solubility	Soluble in DMSO (10 mg/ml) and Ethanol (25 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell

Additional Information

MDL Number	MFCD03453074
ChemACX	X1192611-1
InChI	InChI=1S/C24H24O7/c1-14(2)4-6-17-12-15(5-11-19(17)26)13-24(23(29)30-3)20(21(27)22(28)31-24)16-7-9-18(25)10-8-16/h4-5,7-12,25-27H,6,13H2,1-3H3
SMILES	CC(=CCc1cc(ccc1O)CC2(C(=C(C(=O)O2)O)c3ccc(cc3)O)C(=O)OC)C

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