Bortezomib

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产品名称: Bortezomib

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简单介绍

CAS:179324-69-7Formula:C19H25BN4O4MW:384.24Appearance:Whitetooff-whiteSolidPurity:99%byHPLC

Bortezomib 的详细介绍

A potent (K = 0.6 nM), specific and reversible proteasome inhibitor. It inhibits cell proliferation of H460 cells (Human non-small cell lung cancer cell lines) with an ICof 0.1 M.

Additional Information

Synonyms	MG-341; ((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid;PS-341
Product #	P-2408
CAS #	179324-69-7
Chemical Name	MG-341; ((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid
Formula	C₁₉H₂₅BN₄O₄
MW	384.24
Appearance	White to off-white Solid
Purity	99% by HPLC
Solubility	DMSO (200mg/ml) or EtOH (200 mg/ml)
Melting Point	139-143 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Bortezomib is a selective and robust 26S proteasome inhibitor, that is a boronic acid dipeptide derivative use in cancer

Additional Information

MDL Number	MFCD09056737
ChemACX	X1511968-5
InChI	InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
SMILES	B([C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c2cnccn2)(O)O

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