Bleomycin Sulfate

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产品名称: Bleomycin Sulfate

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简单介绍

CAS:9041-93-4Formula:2C55H84N17O21S3.O4SMW:2927.19Appearance:WhiteCrystalline/PowderPurity:98%

Bleomycin Sulfate 的详细介绍

Anti-neoplastic antibiotic from streptomyces verticillus, mixture of Bleomycin A2, B2, B4. Bleomycin sulfate binds to DNA, and can inhibit DNA synthesis and causes scission of DNA. Cleaves DNA, requires binding to oxygen and a metal ion, such as copper or iron. Able to cleave RNA, but at lessand more selective degree. Also reported to induce and regulate apoptosis in a variety of cells, and inhibit tumor angiogenesis.

Additional Information

Synonyms	Bleo; Blenoxane; Blexane
Product #	B-1269
CAS #	9041-93-4
Chemical Name	3-[[2-[2-[2-[[(2R,3R)-2-[[(2S,3S,4R)-4-[[(2R,3R)-2-[[6-AMINO-2-[(1S)-3-AMINO-1-[[(2S)-2,3-DIAMINO-3-OXOPROPYL]AMINO]-3-OXOPROPYL]-5-METHYLPYRIMIDINE-4-CARBONYL]AMINO]-3-[(2R,3S,4S,5S,6S)-3-[(2S,3S,4R,5R,6R)-4-CARBAMOYLOXY-3,5-DIHYDROXY-6-(HYDROXYMETHYL)OX
Formula	₂ C₅₅ H₈₄ N₁₇ O₂₁ S₃ . O₄ S
MW	2927.19
Appearance	White Crystalline / Powder
Purity	98%
Solubility	Soluble in Water or Methanol
Melting Point	200-204 °C
Preparation	Stock solutions can be store <3 months at +4C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Bleomycin Sulfate is anti-neoplastic antibiotic from streptomyces verticillus

Additional Information

MDL Number	MFCD00070310
ChemACX	X1017354-5
InChI	InChI=1S/2C55H83N17O21S3.H2O4S/c21-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-66-26)91-54-43(39(80)37(78)28(16-73)90-54)92-53-40(81)42(93-55(60)88)38(79)29(17-74)89-53)51(87)67-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-68-27(18-94-32)52-65-15-30(95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h214-15,18-19,21-25,28-29,34-43,53-54,64,73-75,77-81H,7-13,16-17,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,66,67,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t2*21-,22+,23+,24-,25-,28-,29+,34+,35+,36-,37+,38+,39-,40-,41-,42+,43-,53-,54-;/m00./s1
SMILES	Cc1c(nc(nc1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@H]([C@H](c2cnc[nH]2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@H]4[C@H]([C@@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@H]([C@@H](C)O)C(=O)NCCc5nc(cs5)c6ncc(s6)C(=O)NCCC[

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