Blasticidin S HCl

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产品名称: Blasticidin S HCl

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简单介绍

CAS:3513-03-9Formula:C17H26N8O5.HClMW:458.9Appearance:WhitePowderPurity:>98%

Blasticidin S HCl 的详细介绍

Blasticidin S.H.cl is an aminoacylnucleoside antibiotic isolated from Streptomyces griseochromogenes. It shows high efficacy against both eukaryotic and prokaryotic cells. Aside from its antimicrobial properties, blasticidin has displayed antiviral, antitumor, and antifungal properties and has been used as a selection agent. It has been used to select for cells containing the bls, bsr, or BSD resistance gene as well as HEK293-T cells and HEK-D5 cells. Additionally, blasticidin is effective in preventing cell culture contamination and studying protein synthesis.

Blasticidin S.Hcl functions by inhibiting peptide bond formation at the ribosome. It blocks hydrolysis of peptidyl-tRNA due to the large ribosomal subunit's increased affinity for tRNA. Blasticidin S.Hcl has a longstanding application as a gene selection antibiotic and has a powerful new role in Genome editing utilizing the CRISPR/Cas9 system.

Additional Information

Product #	B-1247
CAS #	3513-03-9
Chemical Name	(2S,3S,6R)-3-[[(3S)-3-AMINO-5-[CARBAMIMIDOYL(METHYL)AMINO]PENTANOYL]AMINO]-6-(4-AMINO-2-OXOPYRIMIDIN-1-YL)-3,6-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID HYDROCHLORIDE
Formula	C₁₇H₂₆N₈O₅.HCl
MW	458.9
Appearance	White Powder
Purity	>98%
Solubility	Soluble in water. Clear and faint yellow solution at 5 mg/ml in water. Insoluble in organic solvents.
Melting Point	218.0-225.0 °C
Storage Temp	Store desiccated at +4°C. Protect from moisture.
Use	An antibiotic inhibiting protein synthesis

Additional Information

MDL Number	MFCD02091640
ChemACX	X1339381-2
InChI	InChI=1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H
SMILES	[H]/N=C(N)/N(C)CCC(CC(=O)NC1C=CC(OC1C(=O)O)n2ccc(nc2=O)N)N.Cl

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