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Artemisinin

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产品名称: Artemisinin
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简单介绍

CAS:63968-64-9Formula:C15H22O5MW:282.4Appearance:Whiteneedle-likecrystalsPurity:98%byHPLC


Artemisinin  的详细介绍

Artemisinin is an antimalarial drug. It is an endoperoxide sesquiterpene lactone isolated from the aerial parts of Artemisia annua. Artemisinin is a chemical compound that reacts with iron to form free radicals which can kill cells. Cancer cells are more susceptible to the cytotoxic effect of artemisinin than normal cells. Studies have suggested that artemisinin-tagged transferrin is highly selective and potent in killing cancer cells. Thus, artemisinin and artemisinin-tagged iron-carrying compounds could be developed into powerful anticancer drugs.

 

References:

.Development of artemisinin compounds for cancer treatment. - Lai HC1, Singh NP, Sasaki T.

Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds. - Lai H1, Sasaki T, Singh NP.

 

 

Additional Information

SynonymsArteannuin, Qinghosu, Huanghuanhaosu
Product #A-2426
CAS #63968-64-9
Chemical Name(3R, 5aS, 6R, 8aS, 9R, 12S, 12aR)- Octahydro-3, 6, 9-trimethyl-3, 12-epoxy-12H-pyrano (4, 3-j)-1, 2-benzodioxepin-10(3H)-one
FormulaC15H22O5
MW282.4
AppearanceWhite needle-like crystals
Purity98% by HPLC
SolubilitySoluble in 10mg/ml Methanol, or 10mg/ml DMSO, or 10mg/ml Ethyl Acetate, all giving clear colorless solution.  Soluble in Methanol, Ethanol (up to 1.5%), w/v, DMF, DMSO, acetone; Ethyl Acetate: up to 10% w/v, Almost insoluble in water (<100mg/L)
Melting Point150°C
Storage Temp-18°C
Therapeutic AreaInfectious Diseases
UseAn antimalarial agent that inhibits VEGF expression and NOS2

Additional Information

Merck IndexMerck Index 14: 817
MDL NumberMFCD00081057
ChemACXX1009651-4
InChIInChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1
SMILESC[C@@H]1CC[C@H]2[C@H](C(=O)O[C@H]3[C@@]24[C@H]1CCC(O3)(OO4)C)C
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