Apigenin is an antioxidant flavonoid and a selective inhibitor of CK2. Has chemopreventive and antitumor properties. Induces apoptosis. Also it induces gastric relaxation in mouse stomach, mainly by suppressing Ca2+ influx through voltage-dependent calcium channels. Inhibits the proliferation of malignant tumor cells by G2/M arrest. Is a MAP-Kinase (MAPK/ERK)inhibitor. Inhibits hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression. In WEHI 231 cells inhibition of CK2 by apigenin decreased the rate of IκBα turnover and nuclear levels of NF-κB (20 μM). It blocks proliferation of Wnt-1 transfected cells and abrogates phosphorylation of β-catenin.
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