Apicidin

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产品名称: Apicidin

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简单介绍

CAS:183506-66-3Formula:C34H49N5O6MW:623.8Appearance:WhitetoOff-whitePurity:95%(HPLC)

Apicidin 的详细介绍

A potent oral chemotherapeutic agent,exhibiting anti histone deacetylase activity. Apicidin also has antiproliferative and cytodifferentiation properties.It has been shown to exhibit antitumor effects in several human cancer cell lines.

Additional Information

Synonyms	cyclo-L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl
Product #	A-1264
CAS #	183506-66-3
Chemical Name	cyclo-L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl
Formula	C₃₄H₄₉N₅O₆
MW	623.8
Appearance	White to Off-white
Purity	95% (HPLC)
Solubility	Soluble in DMSO (1mg/ml)
Melting Point	190°C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An HDAC inhibitor and apoptosis inducer use in human ovarian cancer cell

Additional Information

MDL Number	MFCD03452661
ChemACX	X1430043-3
InChI	InChI=1S/C33H47N5O6/c1-5-21(3)28-33(43)37-19-13-12-18-27(37)31(41)34-25(16-9-7-8-14-22(39)6-2)30(40)36-29(32(42)35-28)24-20-38(44-4)26-17-11-10-15-23(24)26/h10-11,15,17,20-21,25,27-29H,5-9,12-14,16,18-19H2,1-4H3,(H,34,41)(H,35,42)(H,36,40)/t21-,25+,27-,28+,29-/m1/s1
SMILES	CC[C@@H](C)[C@H]1C(=O)N2CCCC[C@@H]2C(=O)N[C@H](C(=O)N[C@@H](C(=O)N1)c3cn(c4c3cccc4)OC)CCCCCC(=O)CC

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