Antiserum to-Bcl-X L/S (Purified)

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产品名称: Antiserum to-Bcl-X L/S (Purified)

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简单介绍

Appearance:Liquid.100µgofpurifiedantibodyin1mlof0.05Msodiumphosphatebuffercontaining0.1%sodiumazideand0.2%gelatin.

Antiserum to-Bcl-X L/S (Purified) 的详细介绍

Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 201-216 of human Bcl-X. Specificity: Recognizes human, mouse, rat Bcl-XL (strongly) and Bcl-XS (moderately). Application: IHC (FS, PS), WB.

Bcl-2 and Bcl-XL are anti-apoptotic paralogues that inhibit apoptosis elicited by a wide variety of stimuli, and play critical roles in cancer development and resistance to treatment. Many clinical studies have indicated that expression of these anti-apoptotic proteins in tumours is associated with poor prognosis. It has therefore been assumed that in cells the essential difference between Bcl-2 and Bcl-XL involves regulation of expression and that they are otherwise functionally similar.

Attached?are a?few published references from researchers who have used our Antiserum product. We respectfully thank them for their trust in our product. Inquire for a full reference list.

NEUROSCIENCE: ?Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons,?Hongmei Li, Yingbei Chen, Adrienne F. Jones, et al.,?PNAS, Feb 2008; 105: 2169 - 2174.
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CELLULAR/MOLECULAR: ?Zinc-Dependent Multi-Conductance Channel Activity in Mitochondria Isolated from Ischemic Brain,?Laura Bonanni, Mushtaque Chachar, Teresa Jover-Mengual, et al.,?J. Neurosci., Jun 2006; 26: 6851 - 6862.
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Additional Information

Product #	B-1225
Appearance	Liquid. 100 μg of purified antibody in 1ml of 0.05M sodium phosphate buffer containing 0.1% sodium azide and 0.2% gelatin.
Solubility	Soluble in acetone, dichloromethane, diethyl ether or DMSO.
Storage Temp	+4°C

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