Amphomycin

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产品名称: Amphomycin

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简单介绍

CAS:1402-82-0Formula:C58H91N13O20MW:1290.4Appearance:Off-whitetofawnsolidPurity:>95%byHPLC

Amphomycin 的详细介绍

*Please inquire the availability for this product. Amphomycin is a lipopeptide antibiotic produced by Streptomycetes and Actinoplanes, initially reported by researchers at Bristol-Myers in 1953 from Streptomyces canus. Amphomycin was marketed as a complex of closely related analogues in the 1950s and 1960s. Structure elucidation was not completed until 2000. Amphomycin is active against Gram positive bacteria, inhibiting peptidoglycan synthesis and blocking cell wall development. Amphomycin is closely related to a number of “lost” antibiotics, aspartocin, crystallomycin, glumamycin, friulimicin, laspartocin, tsushimycin and zaomycin. Interest in amphomycin was re-awakened with the discovery of friulimicin activity against antibiotic resistant strains.

Additional Information

Synonyms	Glumamycin, Amfomycin, A1437E
Product #	A-2597
CAS #	1402-82-0
Chemical Name	N-(10-METHYL-3-DODECENOYL)-A-ASPARTYL-3-METHYL-A-ASPARTYL-A-ASPARTYLGLYCYL-A-ASPARTYL-N-(3-AMINO-1-([1-(2-([1-(6,9-DIOXOOCTAHYDRO-2H-PYRIDO[1,2-A]PYRAZIN-7-YL)ETHYL]CARBAMOYL)-1-PYRROL IDINYL)-3-METHYL-1-OXO-2-BUTANYL]AMINO)-1-OXO-2-BUTANYL)GLYCINAMIDE
Formula	C58H91N13O20
MW	1290.4
Appearance	Off-white to fawn solid
Purity	>95% by HPLC
Therapeutic Area	Infectious Diseases
Use	Amphomycin is active against Gram positive bacteria

Additional Information

MDL Number	MFCD00864954
InChI	InChI=1S/C58H91N13O20/c1-8-30(4)16-13-11-9-10-12-14-18-41(73)64-37(25-46(80)81)52(84)69-48(31(5)58(90)91)54(86)66-36(24-45(78)79)51(83)61-27-42(74)65-35(23-44(76)77)50(82)62-28-43(75)67-49(32(6)59)55(87)68-47(29(2)3)57(89)70-20-15-17-38(70)53(85)63-33(7)34-22-40(72)39-26-60-19-21-71(39)56(34)88/h12,14,29-39,47-49,60H,8-11,13,15-28,59H2,1-7H3,(H,61,83)(H,62,82)(H,63,85)(H,64,73)(H,65,74)(H,66,86)(H,67,75)(H,68,87)(H,69,84)(H,76,77)(H,78,79)(H,80,81)(H,90,91)/b14-12+
SMILES	CCC(C)CCCCC/C=C/CC(=O)NC(CC(=O)O)C(=O)NC(C(C)C(=O)O)C(=O)NC(CC(=O)O)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NCC(=O)NC(C(C)N)C(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC(C)C2CC(=O)C3CNCCN3C2=O
Peptide Sequence	N-(10-METHYL-3-DODECENOYL)-A-ASPARTYL-3-METHYL-A-ASPARTYL-A-ASPARTYLGLYCYL-A-ASPARTYL-N-(3-AMINO-1-([1-(2-([1-(6,9-DIOXOOCTAHYDRO-2H-PYRIDO[1,2-A]PYRAZIN-7-YL)ETHYL]CARBAMOYL)-1-PYRROL IDINYL)-3-METHYL-1-OXO-2-BUTANYL]AMINO)-1-OXO-2-BUTANYL)GLYCINAMIDE

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