Amlexanox

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产品名称: Amlexanox

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简单介绍

CAS:68302-57-8Formula:C16H14N2O4MW:298.3Appearance:WhitecrystallinesolidPurity:≥98%

Amlexanox 的详细介绍

Amlexanox improves obesity-related metabolic dysfunction in mouse models. It increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1(TBK1) and IKKԑ (IC₅₀=1.2 µM)².
Clinically useful in treatment of aphthus ulsers.

amlexanox induces the complete and reversible non-apoptotic inhibition of cell migration and proliferation, and although amlexanox does not induce either the down-regulation of F-actin levels or the depolymerization of actin filaments, it does induce the tyrosine phosphorylation of cortactin, a Src substrate known to regulate actin bundling.

Amlexanox, a newly discovered treatment for obesity?

Product References

1. L Koch Nat. Rev. Endocrinol. 2013 9:185

2. SM Reilly et al. Nat. Med. 2012 19:313

3. L Matteo et al. J.Biol.Chem 2000 275:32573

Additional Information

Synonyms	Amoxanox; AA-673; CHX-3673; Aphthasol; Elics; Solfa
Product #	A-2431
CAS #	68302-57-8
Chemical Name	2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid
Formula	C₁₆H₁₄N₂O₄
MW	298.3
Appearance	White crystalline solid
Purity	≥98%
Solubility	May be dissolved in DMSO (60mg/ml). Insoluble in ethanol.
Storage Temp	Store desIccated as supplied at RT for up to 2 years. Store solutions at -20°C for up to 3 months.

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