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Aminopterin

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产品名称: Aminopterin
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简单介绍

CAS:54-62-6Formula:C19H20N8O5MW:440.418Appearance:Solid


Aminopterin  的详细介绍
Dihydrofolate reductase inhibitor; blocks nucleotide synthesis

Additional Information

Product #A-2535
CAS #54-62-6
Chemical NameN-[4-[[(2,4-DIAMINO-6-PTERIDINYL)METHYL]AMINO]BENZOYL]-L-GLUTAMIC ACID
FormulaC19 H20 N8 O5
MW440.418
AppearanceSolid
SolubilitySoluble in water (partly), 0.1N NaOH, DMSO, NH4OH 2M (49.00 - 51.00 mg/ml), and ethanol 
Melting Point225 °C
Storage TempRoom Temp
Therapeutic AreaOncological Disorders
UseAminopterin is a folic acid antagonist. Potent DHFR (dihydrofolate reductase) inhibitor.

Additional Information

MDL NumberMFCD00036692
ChemACXX1006304-8
InChIInChI=1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)
Peptide Sequencec1cc(ccc1C(=O)NC(CCC(=O)O)C(=O)O)NCc2cnc3c(n2)c(nc(n3)N)N
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