Amidepsine D

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产品名称: Amidepsine D

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简单介绍

Formula:C26H24O10MW:496.5Appearance:WhitetolightpinkPowderPurity:95%(HPLC)

Amidepsine D 的详细介绍

Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC=17.5 M) and Raji cells (IC=2.8 M). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.

Additional Information

Product #	A-1450
Chemical Name	4-[(2,4-DIMETHOXY-6-METHYLBENZOYL)OXY]-2-HYDROXY-6-METHYL-BENZOIC ACID 4-CARBOXY-3-HYDROXY-5-METHYLPHENYL ESTER
Formula	C₂₆H₂₄O₁₀
MW	496.5
Appearance	White to light pink Powder
Purity	95% (HPLC)
Solubility	Soluble in methanol (1mg/ml); insoluble in water
Storage Temp	-20°C
Therapeutic Area	Vascular Disorders
Use	Amidepsine A is an inhibitor of DGAT (diacylglycerol acyltransferase) use in atherosclerosis, diabetes and metabolic disorders

Additional Information

MDL Number	MFCD28138426
InChI	InChI=1S/C26H24O10/c1-12-7-16(9-18(27)21(12)24(29)30)35-25(31)22-13(2)8-17(10-19(22)28)36-26(32)23-14(3)6-15(33-4)11-20(23)34-5/h6-11,27-28H,1-5H3,(H,29,30)
SMILES	CC1=CC(=CC(=C1C(=O)O)O)OC(=O)C2=C(C=C(C=C2C)OC(=O)C3=C(C=C(C=C3C)OC)OC)O

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