Alsterpaullone 237430-03-4 CDK inhibitor is an in vitro Anti-Tumor agent, Alste

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产品名称: Alsterpaullone 237430-03-4 CDK inhibitor is an in vitro Anti-Tumor agent, Alste

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简单介绍

CAS:237430-03-4Formula:C16H11N3O3MW:293.38Appearance:BrownPowderPurity:95%

Alsterpaullone 237430-03-4 CDK inhibitor is an in vitro Anti-Tumor agent, Alste 的详细介绍

Paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. Alsterpaullone is a potent inhibitor of CDK/cyclin B (IC=0.035M). High in vitro anti-tumor potency.Cell Cycle-regulated Phosphorylation of Hamartin, the Product of the Tuberous Sclerosis Complex 1 Gene, by Cyclin-dependent Kinase 1/Cyclin B.Formation of the head organizer in hydra involves the canonical Wnt pathway.From the Cover: Wnt/-Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra.

Additional Information

Synonyms	9-Nitropaullone, 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
Product #	A-1136
CAS #	237430-03-4
Chemical Name	9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
Formula	C₁₆H₁₁N₃O₃
MW	293.38
Appearance	Brown Powder
Purity	95%
Solubility	Soluble in DMSO; Insoluble in Water.
Melting Point	238.72 °C
Storage Temp	+4°C
Therapeutic Area	Neurological Disorders
Use	Alsterpaullone is a potent inhibitor of CDK/cyclin B

Additional Information

MDL Number	MFCD02683579
ChemACX	X1340840-3
InChI	InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
SMILES	c1ccc2c(c1)-c3c(c4cc(ccc4[nH]3)[N+](=O)[O-])CC(=O)N2

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