A nanobioelectronic device incorporating an alamethicin biological pore. In the

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产品名称: A nanobioelectronic device incorporating an alamethicin biological pore. In the

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简单介绍

CAS:27061-78-5Formula:C92H150N22O25MW:1964.4Appearance:Off-whitetobeigepowderPurity:>99%byTLC

A nanobioelectronic device incorporating an alamethicin biological pore. In the 的详细介绍

Alameticin is a linear peptide antibiotic isolated from the fungus Trichoderma viridae. It is linear and consists of 20 amino acid residues. Under proper conditions it can produce action potentials similar to that of nerve axons. Alamethicin is known to exhibit voltage dependent ion channel activity in membrane environments. Alamethicin has a high affinity for lipid bilayers, therefore, alamethicin binds to the surface of lipid bilayers and can be inserted into the membrane.

Alamethicin channels are formed by parallel bundles of the transmembrane helical monomers surrounding a central water-filled pore, and are composed of 3–12 alamethicin molecules. The ion channel activity of alamethicin makes it a suitable model to investigate voltage dependent ion channel proteins. Effective against gram positive bacteria and fungi.

Additional Information

Synonyms	Antibiotic U-22324
Product #	A-1286
CAS #	27061-78-5
Chemical Name	N-Acetyl-2-methylalanyl-L-prolyl-2- methylalanyl-L-alanyl-2-methylalanyl-L-alanyl-Lglutaminyl-2-methylalanyl-L-valyl-2- methylalanylglycyl-L-leucyl-2-methylalanyl-L-prolylL-valyl-2-methylalanyl-2-methylalanyl-L-½‚±-glutamylN1-[(2R)-1-hydroxy-3-phenylpropa
Formula	C₉₂H₁₅₀N₂₂O₂₅
MW	1964.4
Appearance	Off-white to beige powder
Purity	>99% by TLC
Solubility	Soluble in Water
Melting Point	268-271°C
Preparation	Store Solutions at -20°C for up to 2 months.
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	Alamethicin is a peptide antibiotic, produced by the fungus Trichoderma viride

Additional Information

MDL Number	MFCD00151517
ChemACX	X1009632-9
InChI	InChI=1S/C92H150N22O25/c1-47(2)43-58(72(127)108-92(24,25)84(139)113-41-29-33-59(113)73(128)103-65(48(3)4)75(130)111-90(20,21)82(137)112-89(18,19)80(135)102-56(37-40-64(120)121)70(125)101-55(35-38-61(93)117)69(124)98-54(46-115)44-53-31-27-26-28-32-53)99-63(119)45-95-77(132)85(10,11)110-76(131)66(49(5)6)104-81(136)88(16,17)107-71(126)57(36-39-62(94)118)100-67(122)50(7)96-78(133)86(12,13)106-68(123)51(8)97-79(134)87(14,15)109-74(129)60-34-30-42-114(60)83(138)91(22,23)105-52(9)116/h26-28,31-32,47-51,54-60,65-66,115H,29-30,33-46H2,1-25H3,(H2,93,117)(H2,94,118)(H,95,132)(H,96,133)(H,97,134)(H,98,124)(H,99,119)(H,100,122)(H,101,125)(H,102,135)(H,103,128)(H,104,136)(H,105,116)(H,106,123)(H,107,126)(H,108,127)(H,109,129)(H,110,131)(H,111,130)(H,112,137)(H,120,121)/t50-,51-,54-,55-,56-,57-,58-,59-,60-,65-,66-/m0/s1
SMILES	C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)NC(C)(C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc2ccccc2)CO)NC(=O)C(C
Peptide Sequence	AC-AIB-PRO-AIB-ALA-AIB-ALA-GLN-AIB-VAL-AIB-GLY-LEU-AIB-PRO-VAL-AIB-AIB-GLU-GLN-PHENYLALANINOL

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