ABT-888

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产品名称: ABT-888

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简单介绍

CAS:912445-05-7Formula:C13H16N4O.2HClMW:317.21Appearance:ColorelesstowhitecrystallineSolidPurity:98%byHPLC

ABT-888 的详细介绍

Potent inhibitor of PARP-1 and PARP-2 (potency 5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radio-potentiation. Does not show inherent cytotoxicity and shows no single agent activity in tumor models.

Additional Information

Synonyms	2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide dihydrochloride
Product #	A-2178
CAS #	912445-05-7
Chemical Name	2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide . dihydrochloride
Formula	C₁₃H₁₆N₄O.₂HCl
MW	317.21
Appearance	Coloreless to white crystalline Solid
Purity	98% by HPLC
Solubility	Soluble in DMSO and H₂O
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	ABT-888 has been shown to inhibit PARP-1 and PARP-2 for treatment of colon cancer

Additional Information

MDL Number	MFCD12407402
ChemACX	X1812318-5
InChI	InChI=1S/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12;;/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17);2*1H/t13-;;/m1../s1
SMILES	C[C@@]1(CCCN1)c2[nH]c3cccc(c3n2)C(=O)N.Cl.Cl

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