A83-01

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产品名称: A83-01

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简单介绍

CAS:909910-43-6Formula:C25H19N5SMW:421.52Appearance:PaleYellowSolidPurity:98%byHPLC

A83-01 的详细介绍

A selective inhibitor of TGF-type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-induced epithelial-to-mesenchymal transition. Helps maintain homogeneity and long-term in vitro self-renewal of human induced pluripotent stem cells (iPSCs)

Additional Information

Synonyms	3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Product #	A-1764
CAS #	909910-43-6
Chemical Name	3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Formula	C₂₅H₁₉N₅S
MW	421.52
Appearance	Pale Yellow Solid
Purity	98% by HPLC
Solubility	DMSO (50 mM)
Storage Temp	Store at -20°C
Therapeutic Area	Oncological Disorders
Use	An inhibitor of TGF-β type I receptor ALK5 kinase signaling facilitates tumor growth and metastasis in Metastatic Cancer

Additional Information

MDL Number	MFCD08705403
ChemACX	X1543876-9
InChI	InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)
SMILES	Cc1cccc(n1)c2c(cn(n2)C(=S)Nc3ccccc3)c4ccnc5c4cccc5

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